Do peptides interact with other medicines?
A free peptide drug interaction checker, straight from FDA labels.
Short answer: Some peptide medicines do interact with other drugs. The FDA labels for Zepbound and Mounjaro say birth control pills may not work as well for a while, so use a non-pill method or add condoms for 4 weeks after starting and after each dose increase. GLP-1 shots slow your stomach and raise low blood sugar risk with insulin. Unapproved peptides like BPC-157 were never tested with other drugs.
By the Peptide Science Desk Editorial TeamFact-checked against FDA and official sources · Not yet reviewed by a licensed clinician. How we check facts
Turn on JavaScript to switch medicines. Every medicine is also listed further down this page.
GLP-1: Zepbound (tirzepatide)FDA label
FDA status: FDA approved
What the FDA label says about other medicines
- Birth control pills: Birth control pills may not work as well. The label says to switch to a non-pill method, or add a barrier method like condoms, for 4 weeks after starting and for 4 weeks after each dose increase. Birth control that is not a pill (patch, ring, shot, IUD, implant) should not be affected.
- Any medicine taken by mouth: Slows how fast your stomach empties. That can change how other pills are absorbed. The label says to use care and watch how your other pills work.
- Blood thinner warfarin, or other "narrow" drugs: The label says doctors should watch people on pills that must stay at an exact level to work, and "narrow" drugs like warfarin.
- Insulin or diabetes pills (sulfonylureas): Raises the risk of low blood sugar when used with insulin or a sulfonylurea pill (like glipizide). The label tells doctors to think about lowering those drugs. Do not change them on your own.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
Or start with a medicine you take
Do peptides interact with birth control?
Yes for tirzepatide. The Zepbound and Mounjaro labels say birth control pills may not work as well. Use a non-pill method, or add a barrier method, for 4 weeks after starting and 4 weeks after each dose increase.
Birth control that is not a pill (patch, ring, shot, IUD or implant) should not be affected, the labels say.
The semaglutide labels (Wegovy, Ozempic) do not have this warning. For retatrutide and other unapproved peptides there is no label at all.
Can GLP-1 drugs cause low blood sugar with insulin?
Yes. The labels for Wegovy, Ozempic, Zepbound and Mounjaro say the risk of low blood sugar goes up with insulin or sulfonylurea pills.
The labels tell doctors to think about lowering those drugs. Never do this on your own.
Why do GLP-1 shots change how other pills work?
They slow how fast food and pills leave your stomach. That can change when and how much of a pill gets into your blood.
This matters most for pills that must stay at an exact level, like warfarin or levothyroxine. Your doctor may check your levels more often.
Does BPC-157 interact with other drugs?
Nobody knows. BPC-157 is not FDA approved, and we found no drug interaction studies in people.
Unknown is not the same as safe. Tell your doctor and pharmacist about every peptide you use, including ones bought online.
Which peptide labels warn about which medicines
15 peptide drugs × 9 kinds of medicine. Based on section 7 of each FDA label
- Label has a warning or caution
- Label checked: no special warning
- Not mentioned on the label
- No label or no studies: unknown
- 1 Birth control pills
- 2 Insulin or diabetes pills (sulfonylureas)
- 3 Thyroid pills (levothyroxine)
- 4 Blood thinner warfarin, or other "narrow" drugs
- 5 Any medicine taken by mouth
- 6 Antibiotics or pain pills that must work fast
- 7 Naltrexone (for alcohol or opioid use)
- 8 Steroid pills (prednisone, cortisone)
- 9 Heart drug digoxin
| Drug | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|---|---|---|---|---|---|---|---|---|
| Wegovysemaglutide | ✓Birth control pills: Label checked: no special warning | !Insulin or diabetes pills (sulfonylureas): Label has a warning or caution | !Thyroid pills (levothyroxine): Label has a warning or caution | !Blood thinner warfarin, or other "narrow" drugs: Label has a warning or caution | !Any medicine taken by mouth: Label has a warning or caution | ·Antibiotics or pain pills that must work fast: Not mentioned on the label | ·Naltrexone (for alcohol or opioid use): Not mentioned on the label | ·Steroid pills (prednisone, cortisone): Not mentioned on the label | ·Heart drug digoxin: Not mentioned on the label |
| Ozempicsemaglutide shot | ✓Birth control pills: Label checked: no special warning | !Insulin or diabetes pills (sulfonylureas): Label has a warning or caution | ·Thyroid pills (levothyroxine): Not mentioned on the label | ·Blood thinner warfarin, or other "narrow" drugs: Not mentioned on the label | !Any medicine taken by mouth: Label has a warning or caution | ·Antibiotics or pain pills that must work fast: Not mentioned on the label | ·Naltrexone (for alcohol or opioid use): Not mentioned on the label | ·Steroid pills (prednisone, cortisone): Not mentioned on the label | ·Heart drug digoxin: Not mentioned on the label |
| Rybelsus or Ozempic tabletssemaglutide pills | ✓Birth control pills: Label checked: no special warning | !Insulin or diabetes pills (sulfonylureas): Label has a warning or caution | !Thyroid pills (levothyroxine): Label has a warning or caution | !Blood thinner warfarin, or other "narrow" drugs: Label has a warning or caution | !Any medicine taken by mouth: Label has a warning or caution | ·Antibiotics or pain pills that must work fast: Not mentioned on the label | ·Naltrexone (for alcohol or opioid use): Not mentioned on the label | ·Steroid pills (prednisone, cortisone): Not mentioned on the label | ·Heart drug digoxin: Not mentioned on the label |
| Zepboundtirzepatide | !Birth control pills: Label has a warning or caution | !Insulin or diabetes pills (sulfonylureas): Label has a warning or caution | ·Thyroid pills (levothyroxine): Not mentioned on the label | !Blood thinner warfarin, or other "narrow" drugs: Label has a warning or caution | !Any medicine taken by mouth: Label has a warning or caution | ·Antibiotics or pain pills that must work fast: Not mentioned on the label | ·Naltrexone (for alcohol or opioid use): Not mentioned on the label | ·Steroid pills (prednisone, cortisone): Not mentioned on the label | ·Heart drug digoxin: Not mentioned on the label |
| Mounjarotirzepatide | !Birth control pills: Label has a warning or caution | !Insulin or diabetes pills (sulfonylureas): Label has a warning or caution | ·Thyroid pills (levothyroxine): Not mentioned on the label | !Blood thinner warfarin, or other "narrow" drugs: Label has a warning or caution | !Any medicine taken by mouth: Label has a warning or caution | ·Antibiotics or pain pills that must work fast: Not mentioned on the label | ·Naltrexone (for alcohol or opioid use): Not mentioned on the label | ·Steroid pills (prednisone, cortisone): Not mentioned on the label | ·Heart drug digoxin: Not mentioned on the label |
| Saxendaliraglutide | ✓Birth control pills: Label checked: no special warning | ·Insulin or diabetes pills (sulfonylureas): Not mentioned on the label | ·Thyroid pills (levothyroxine): Not mentioned on the label | ·Blood thinner warfarin, or other "narrow" drugs: Not mentioned on the label | !Any medicine taken by mouth: Label has a warning or caution | ·Antibiotics or pain pills that must work fast: Not mentioned on the label | ·Naltrexone (for alcohol or opioid use): Not mentioned on the label | ·Steroid pills (prednisone, cortisone): Not mentioned on the label | ·Heart drug digoxin: Not mentioned on the label |
| Vyleesibremelanotide, PT-141 | ·Birth control pills: Not mentioned on the label | ·Insulin or diabetes pills (sulfonylureas): Not mentioned on the label | ·Thyroid pills (levothyroxine): Not mentioned on the label | ·Blood thinner warfarin, or other "narrow" drugs: Not mentioned on the label | !Any medicine taken by mouth: Label has a warning or caution | !Antibiotics or pain pills that must work fast: Label has a warning or caution | !Naltrexone (for alcohol or opioid use): Label has a warning or caution | ·Steroid pills (prednisone, cortisone): Not mentioned on the label | ·Heart drug digoxin: Not mentioned on the label |
| Egrifta SVtesamorelin | ·Birth control pills: Not mentioned on the label | ·Insulin or diabetes pills (sulfonylureas): Not mentioned on the label | ·Thyroid pills (levothyroxine): Not mentioned on the label | ·Blood thinner warfarin, or other "narrow" drugs: Not mentioned on the label | !Any medicine taken by mouth: Label has a warning or caution | ·Antibiotics or pain pills that must work fast: Not mentioned on the label | ·Naltrexone (for alcohol or opioid use): Not mentioned on the label | !Steroid pills (prednisone, cortisone): Label has a warning or caution | ·Heart drug digoxin: Not mentioned on the label |
| Forteoteriparatide | ·Birth control pills: Not mentioned on the label | ·Insulin or diabetes pills (sulfonylureas): Not mentioned on the label | ·Thyroid pills (levothyroxine): Not mentioned on the label | ·Blood thinner warfarin, or other "narrow" drugs: Not mentioned on the label | ·Any medicine taken by mouth: Not mentioned on the label | ·Antibiotics or pain pills that must work fast: Not mentioned on the label | ·Naltrexone (for alcohol or opioid use): Not mentioned on the label | ·Steroid pills (prednisone, cortisone): Not mentioned on the label | !Heart drug digoxin: Label has a warning or caution |
| Tymlosabaloparatide | ?Birth control pills: No label or no studies: unknown | ?Insulin or diabetes pills (sulfonylureas): No label or no studies: unknown | ?Thyroid pills (levothyroxine): No label or no studies: unknown | ?Blood thinner warfarin, or other "narrow" drugs: No label or no studies: unknown | ?Any medicine taken by mouth: No label or no studies: unknown | ?Antibiotics or pain pills that must work fast: No label or no studies: unknown | ?Naltrexone (for alcohol or opioid use): No label or no studies: unknown | ?Steroid pills (prednisone, cortisone): No label or no studies: unknown | ?Heart drug digoxin: No label or no studies: unknown |
| Retatrutide"reta" | ?Birth control pills: No label or no studies: unknown | ?Insulin or diabetes pills (sulfonylureas): No label or no studies: unknown | ?Thyroid pills (levothyroxine): No label or no studies: unknown | ?Blood thinner warfarin, or other "narrow" drugs: No label or no studies: unknown | ?Any medicine taken by mouth: No label or no studies: unknown | ?Antibiotics or pain pills that must work fast: No label or no studies: unknown | ?Naltrexone (for alcohol or opioid use): No label or no studies: unknown | ?Steroid pills (prednisone, cortisone): No label or no studies: unknown | ?Heart drug digoxin: No label or no studies: unknown |
| BPC-157 | ?Birth control pills: No label or no studies: unknown | ?Insulin or diabetes pills (sulfonylureas): No label or no studies: unknown | ?Thyroid pills (levothyroxine): No label or no studies: unknown | ?Blood thinner warfarin, or other "narrow" drugs: No label or no studies: unknown | ?Any medicine taken by mouth: No label or no studies: unknown | ?Antibiotics or pain pills that must work fast: No label or no studies: unknown | ?Naltrexone (for alcohol or opioid use): No label or no studies: unknown | ?Steroid pills (prednisone, cortisone): No label or no studies: unknown | ?Heart drug digoxin: No label or no studies: unknown |
| TB-500 | ?Birth control pills: No label or no studies: unknown | ?Insulin or diabetes pills (sulfonylureas): No label or no studies: unknown | ?Thyroid pills (levothyroxine): No label or no studies: unknown | ?Blood thinner warfarin, or other "narrow" drugs: No label or no studies: unknown | ?Any medicine taken by mouth: No label or no studies: unknown | ?Antibiotics or pain pills that must work fast: No label or no studies: unknown | ?Naltrexone (for alcohol or opioid use): No label or no studies: unknown | ?Steroid pills (prednisone, cortisone): No label or no studies: unknown | ?Heart drug digoxin: No label or no studies: unknown |
| CJC-1295 or ipamorelin | ?Birth control pills: No label or no studies: unknown | ?Insulin or diabetes pills (sulfonylureas): No label or no studies: unknown | ?Thyroid pills (levothyroxine): No label or no studies: unknown | ?Blood thinner warfarin, or other "narrow" drugs: No label or no studies: unknown | ?Any medicine taken by mouth: No label or no studies: unknown | ?Antibiotics or pain pills that must work fast: No label or no studies: unknown | ?Naltrexone (for alcohol or opioid use): No label or no studies: unknown | ?Steroid pills (prednisone, cortisone): No label or no studies: unknown | ?Heart drug digoxin: No label or no studies: unknown |
| GHK-Cucopper peptide shots | ?Birth control pills: No label or no studies: unknown | ?Insulin or diabetes pills (sulfonylureas): No label or no studies: unknown | ?Thyroid pills (levothyroxine): No label or no studies: unknown | ?Blood thinner warfarin, or other "narrow" drugs: No label or no studies: unknown | ?Any medicine taken by mouth: No label or no studies: unknown | ?Antibiotics or pain pills that must work fast: No label or no studies: unknown | ?Naltrexone (for alcohol or opioid use): No label or no studies: unknown | ?Steroid pills (prednisone, cortisone): No label or no studies: unknown | ?Heart drug digoxin: No label or no studies: unknown |
"?" means nobody has checked, not that it is safe. Always show your full medicine list to a pharmacist.
Interaction notes for every medicine in this tool
GLP-1: Wegovy (semaglutide)
GLP-1: Wegovy (semaglutide)FDA label
FDA status: FDA approved
What the FDA label says about other medicines
- Any medicine taken by mouth: Slows how fast your stomach empties. That can change how other pills are absorbed. The label says to use care and watch how your other pills work.
- Insulin or diabetes pills (sulfonylureas): Raises the risk of low blood sugar when used with insulin or a sulfonylurea pill (like glipizide). The label tells doctors to think about lowering those drugs. Do not change them on your own.
- Thyroid pills (levothyroxine): In a study with semaglutide tablets, the body absorbed 33% more levothyroxine. The label says doctors may check more often when "narrow" drugs like this are taken with it.
- Blood thinner warfarin, or other "narrow" drugs: The label says to think about more checkups for "narrow" drugs that need close watching.
- Birth control pills: The label has no special birth control warning like the tirzepatide labels do. It still slows the stomach, so ask your pharmacist about any pill you take.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
GLP-1: Ozempic (semaglutide shot)
GLP-1: Ozempic (semaglutide shot)FDA label
FDA status: FDA approved
What the FDA label says about other medicines
- Any medicine taken by mouth: Slows how fast your stomach empties. That can change how other pills are absorbed. The label says to use care and watch how your other pills work.
- Insulin or diabetes pills (sulfonylureas): Raises the risk of low blood sugar when used with insulin or a sulfonylurea pill (like glipizide). The label tells doctors to think about lowering those drugs. Do not change them on your own. The label mentions severe low blood sugar.
- Birth control pills: The label has no special birth control warning like the tirzepatide labels do. It still slows the stomach, so ask your pharmacist about any pill you take.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
GLP-1: Rybelsus or Ozempic tablets (semaglutide pills)
GLP-1: Rybelsus or Ozempic tablets (semaglutide pills)FDA label
FDA status: FDA approved
What the FDA label says about other medicines
- Any medicine taken by mouth: Slows how fast your stomach empties. That can change how other pills are absorbed. The label says to use care and watch how your other pills work.
- Insulin or diabetes pills (sulfonylureas): Raises the risk of low blood sugar when used with insulin or a sulfonylurea pill (like glipizide). The label tells doctors to think about lowering those drugs. Do not change them on your own.
- Thyroid pills (levothyroxine): In a study with semaglutide tablets, the body absorbed 33% more levothyroxine. The label says doctors may check more often when "narrow" drugs like this are taken with it.
- Blood thinner warfarin, or other "narrow" drugs: The label says to think about more checkups for "narrow" drugs that need close watching.
- Birth control pills: The label has no special birth control warning like the tirzepatide labels do. It still slows the stomach, so ask your pharmacist about any pill you take.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
GLP-1: Zepbound (tirzepatide)
GLP-1: Zepbound (tirzepatide)FDA label
FDA status: FDA approved
What the FDA label says about other medicines
- Birth control pills: Birth control pills may not work as well. The label says to switch to a non-pill method, or add a barrier method like condoms, for 4 weeks after starting and for 4 weeks after each dose increase. Birth control that is not a pill (patch, ring, shot, IUD, implant) should not be affected.
- Any medicine taken by mouth: Slows how fast your stomach empties. That can change how other pills are absorbed. The label says to use care and watch how your other pills work.
- Blood thinner warfarin, or other "narrow" drugs: The label says doctors should watch people on pills that must stay at an exact level to work, and "narrow" drugs like warfarin.
- Insulin or diabetes pills (sulfonylureas): Raises the risk of low blood sugar when used with insulin or a sulfonylurea pill (like glipizide). The label tells doctors to think about lowering those drugs. Do not change them on your own.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
GLP-1: Mounjaro (tirzepatide)
GLP-1: Mounjaro (tirzepatide)FDA label
FDA status: FDA approved
What the FDA label says about other medicines
- Birth control pills: Birth control pills may not work as well. The label says to switch to a non-pill method, or add a barrier method like condoms, for 4 weeks after starting and for 4 weeks after each dose increase. Birth control that is not a pill (patch, ring, shot, IUD, implant) should not be affected.
- Any medicine taken by mouth: Slows how fast your stomach empties. That can change how other pills are absorbed. The label says to use care and watch how your other pills work.
- Blood thinner warfarin, or other "narrow" drugs: The label says doctors should watch people on pills that must stay at an exact level to work, and "narrow" drugs like warfarin.
- Insulin or diabetes pills (sulfonylureas): Raises the risk of low blood sugar when used with insulin or a sulfonylurea pill (like glipizide). The label tells doctors to think about lowering those drugs. Do not change them on your own.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
GLP-1: Saxenda (liraglutide)
GLP-1: Saxenda (liraglutide)FDA label
FDA status: FDA approved
What the FDA label says about other medicines
- Any medicine taken by mouth: Slows how fast your stomach empties. In studies it did not change how the tested pills were absorbed in a way that mattered, but the label still says to watch for slower-working pills.
- Birth control pills: The label has no special birth control warning like the tirzepatide labels do. It still slows the stomach, so ask your pharmacist about any pill you take.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
Vyleesi (bremelanotide, PT-141)
Vyleesi (bremelanotide, PT-141)FDA label
FDA status: FDA approved
What the FDA label says about other medicines
- Naltrexone (for alcohol or opioid use): Can greatly lower the amount of naltrexone pills in your body. The label says to avoid using them together when naltrexone treats alcohol or opioid addiction, because that treatment could fail.
- Antibiotics or pain pills that must work fast: May slow your stomach. The label says to avoid Vyleesi with pills that must reach a certain level to work, like antibiotics. If a pain pill (like indomethacin) works too slowly, the label says to think about stopping Vyleesi.
- Any medicine taken by mouth: May slow how fast other pills are absorbed.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
Egrifta SV (tesamorelin)
Egrifta SV (tesamorelin)FDA label
FDA status: FDA approved
What the FDA label says about other medicines
- Steroid pills (prednisone, cortisone): People who take steroid replacement for weak adrenal glands may need more of it after starting. Prednisone and cortisone may be affected most. Your doctor decides this.
- Any medicine taken by mouth: It raises growth hormone, which may change how the liver clears some drugs (like steroids, sex hormones, seizure drugs and cyclosporine). The label says to watch for interactions. In a study it did not change simvastatin levels.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
Forteo (teriparatide)
Forteo (teriparatide)FDA label
FDA status: FDA approved
What the FDA label says about other medicines
- Heart drug digoxin: Forteo can raise blood calcium for a short time. High calcium may make digoxin toxic. The label says to watch for signs of that.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
Tymlos (abaloparatide)
Tymlos (abaloparatide)FDA label
FDA status: FDA approved
What the FDA label says about other medicines
- What is known: The label says no drug interaction studies were done. That means nobody tested it, not that it is safe with everything.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
GLP-1: Retatrutide ("reta")
GLP-1: Retatrutide ("reta")Our page
FDA status: In testing, not FDA approved
What is known
- What is known: There is no FDA label yet, so there is no official interaction list. Products sold online as "reta" are not the tested drug. Ask a pharmacist about birth control and any other medicine.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
BPC-157
BPC-157Our page
FDA status: Not FDA approved
What is known
- What is known: No FDA label and no drug interaction studies in people that we found. Unknown does not mean safe.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
TB-500
TB-500Our page
FDA status: Not FDA approved
What is known
- What is known: No FDA label and no studies in people that we found, so interactions are unknown.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
CJC-1295 or ipamorelin
CJC-1295 or ipamorelinOur page
FDA status: Not FDA approved
What is known
- What is known: No FDA label and no drug interaction studies in people that we found. Unknown does not mean safe.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
GHK-Cu (copper peptide shots)
GHK-Cu (copper peptide shots)Our page
FDA status: Not FDA approved as a drug
What is known
- What is known: No FDA label for shots and no drug interaction studies in people that we found.
Do not stop or change a medicine on your own. Show this list to your pharmacist or doctor.
FAQ
Where does this information come from?
From section 7, "Drug Interactions," of each FDA label on DailyMed and openFDA, checked October 26, 2026. We rewrote it in plain words. Each card links its label.
Can I take retatrutide with birth control?
Retatrutide has no FDA label yet, so there is no official answer. Ask a pharmacist. Products sold online as "reta" are not the tested drug.
Do peptides interact with alcohol?
See our side effects checker. It shows what each label says about alcohol.
Can I take collagen peptides with my medicines?
Collagen powder is a food supplement, not one of the drugs in this tool. Ask your pharmacist.
Is this tool a full interaction check?
No. It only shows what the peptide label says. A pharmacist can check your full list of medicines and supplements.
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