Can peptides make you infertile?

Can peptides make you infertile?

• There is no one answer. Each peptide is a different drug.
• Approved peptide drugs were tested in animals for fertility. The Zepbound label says tirzepatide did not change sperm, mating, fertility, or getting pregnant in rats. Female rats had cycle changes that the label links to eating less and losing weight.
• The Wegovy label says semaglutide had no effect on male fertility in rats. Female rats had longer cycles, which the label links to eating less.
• The Egrifta SV label says tesamorelin did not change fertility in male or female rats at the doses tested.
• Animal tests do not prove what happens in people.
• For most unapproved peptides, like BPC-157, there is no fertility data in people. That means the risk is unknown, not zero.

Are peptides safe during pregnancy?

• Wegovy: the label says weight loss offers no benefit in pregnancy and may harm the baby. It says to stop Wegovy for weight loss when pregnancy is found.
• Zepbound: the label says to stop when pregnancy is found. It says human data is too small to know the risk. Animal studies showed possible harm to the baby.
• Egrifta SV (tesamorelin): the label says it must not be used in pregnancy.
• Vyleesi (bremelanotide, PT-141): the label says the few pregnancies in its trials were too few to know the risk. Animal studies suggest possible harm.
• Unapproved peptides: we found no pregnancy safety data. No data is not proof of safety.
• If you are pregnant or could be, talk to your doctor before using any peptide.
• Studies in people help a little. A big study of babies born to women with type 2 diabetes did not find more birth defects after early GLP-1 use than after insulin. It still needs to be confirmed.
• A 2026 review of 36 human studies found no clear harm from early pregnancy use. It says there is little data on use later in pregnancy.

Can I take peptides while trying to conceive?

• Ask your doctor first, before you start trying.
• The Wegovy label says to stop at least 2 months before a planned pregnancy when you use it for weight loss or heart risk, because semaglutide stays in the body a long time.
• The label for Rybelsus and Ozempic tablets (semaglutide pills) also says to stop at least 2 months before a planned pregnancy.
• Some people trying to conceive ask about peptides like kisspeptin-10. It is not FDA approved, and the FDA says there is little or no safety data for how people use it.

Do Zepbound and Mounjaro affect birth control pills?

• Yes, they may. Their labels say tirzepatide may make birth control pills work less well, because it slows how fast the stomach empties.
• The labels say to switch to a non-pill birth control, or add a barrier method (like condoms), for 4 weeks after starting and for 4 weeks after each dose increase.
• The labels say birth control that is not taken by mouth should not be affected.
• Ask your doctor or pharmacist which birth control fits you.

Can peptides help fertility?

• Some approved peptide hormones are fertility medicines. HCG (Pregnyl, Novarel) is FDA approved to help some women release an egg, and for some men whose low sex hormones come from a pituitary gland problem.
• The HCG labels say it should be used by doctors who know how to treat infertility. It can over-stimulate the ovaries.
• The Pregnyl label says it is not for use in pregnancy. It may be used as support during fertility treatment, and it is stopped once pregnancy is confirmed.
• Gonadorelin was once approved for people as Factrel. FDA now lists the human version as discontinued.
• Kisspeptin-10 is not approved for fertility. Claims that it boosts fertility are not proven.

• HCG page
• Kisspeptin-10 page
• Gonadorelin page

Are peptides safe while breastfeeding?

• Wegovy shots: the label says there is no data on whether semaglutide shots get into breast milk. Talk to your doctor about how to feed your baby.
• Wegovy, Ozempic and Rybelsus tablets: the labels say breastfeeding is not recommended, because of an added ingredient (SNAC) that may build up in babies.
• Zepbound: the label says a small study found tirzepatide in breast milk was not found or was low.
• Egrifta SV: the label says not to breastfeed.
• Unapproved peptides: no data that we found.

Are peptide skin creams or collagen safe in pregnancy?

• We found no FDA pregnancy data for peptide creams or collagen peptide powders.
• The FDA does not approve supplements, like collagen powders, before they are sold.
• Ask your OB doctor, midwife, or pharmacist before you use one while pregnant.

Key studies in people: GLP-1 drugs and pregnancy

We read each study on PubMed on October 28, 2026. We found no pregnancy or fertility studies in people for BPC-157.

What FDA labels say about pregnancy and fertility