Retatrutide

Still being tested, not approved

A new weight-loss shot still in big tests. It is not FDA-approved. Early results showed large weight loss.

Pending medical review Updated October 16, 2026

What is it?

Retatrutide is a peptide medicine made by Eli Lilly. It is still being tested. It acts on 3 body signals that control hunger and sugar.

Why do people use it?

People are excited because early tests showed big weight loss.

Does it really work?

In a 48-week test with 338 adults with obesity, people on the highest dose lost about 24% of their body weight on average. People on a fake shot (placebo) lost about 2%. Bigger tests (phase 3) are still going. It is not approved yet.

Is it safe? Side effects

  • In the early test, the most common problems were in the stomach, like feeling sick. Most were mild to medium.
  • Heart rate went up in a dose-linked way, then came down after 24 weeks.
  • The FDA has warned companies for selling retatrutide labeled "for research" to people. The FDA says these products are of unknown quality and may be harmful.

Talk to your doctor

Do not start any peptide on your own. Ask a doctor first. We never share doses or tell you where to buy. Print our doctor questions sheet.

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FAQ

What is Retatrutide?

Retatrutide is a peptide medicine made by Eli Lilly. It is still being tested. It acts on 3 body signals that control hunger and sugar.

Does Retatrutide work?

In a 48-week test with 338 adults with obesity, people on the highest dose lost about 24% of their body weight on average. People on a fake shot (placebo) lost about 2%. Bigger tests (phase 3) are still going. It is not approved yet.

Is Retatrutide legal in the US?

No. Retatrutide is not FDA-approved. (The FDA is the US agency that checks if medicines are safe and work.) It is only legal to get in an approved clinical trial.

Related pages

Sources

Not medical advice. Medical disclaimer.