Melanotan II

Not enough proof

A lab-made "tanning" peptide. It is not approved, and published reports describe serious harm, including skin cancer.

Pending medical review Updated October 16, 2026

What is it?

Melanotan II is a lab-made peptide. It acts on the body signal that darkens your skin.

Why do people use it?

Some people use it to tan without sun. Some use it for sex drive. These uses are not approved.

Does it really work?

It is not proven safe or helpful. The FDA points to published reports of serious harm in people who used it.

Is it safe? Side effects

  • The FDA says it does not have enough safety facts about Melanotan II in people.
  • The FDA warns your body might fight it like a germ. Doctors call this an immune reaction.
  • Products may have unwanted bits left over from how they were made.
  • The FDA points to published reports of melanoma (a serious skin cancer), a dangerous brain swelling problem called PRES, overdose-like reactions, and painful erections that would not go away.

Talk to your doctor

Do not start any peptide on your own. Ask a doctor first. We never share doses or tell you where to buy. Print our doctor questions sheet.

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FAQ

What is Melanotan II?

Melanotan II is a lab-made peptide. It acts on the body signal that darkens your skin.

Does Melanotan II work?

It is not proven safe or helpful. The FDA points to published reports of serious harm in people who used it.

Is Melanotan II legal in the US?

No. Melanotan II is not an FDA-approved medicine. (The FDA is the US agency that checks if medicines are safe and work.) The FDA put Melanotan II on a list of things that may be risky when a pharmacy mixes them into a medicine.

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Sources

Not medical advice. Medical disclaimer.